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Image 1 - Orphan annie eye nuclei which are the characteristic of Papillary adenocarcinoma. They are enlarged nuclei, nuclear clearing, nuclear contour angulations, peripheral condensation of nuclear chromatin and nuclear grooves. Not all nuclear features can be evident in all cases. Nuclear grooves are shown with long arrows in this case. The central vascular core is shown with arrowheads.
Image 2 - Psammoma bodies can also be seen in 50% case of papillary thyroid cancer which is characterized by dystrophic calcification at center. It is also found in some other tumors like ovarian serous cystadenocarcinoma, meningioma, mesothelioma and others.
Image 3 - Normal thyroid histology
Treatment is hemithyroidectomy (for mass < 1 cm in diameter) or total thyroidectomy (for mass > 1 cm in diameter) and then suppress TSH level (because TSH will stimulate thyroid cells). give thyroid supplements.
Excellent prognosis with 5 year survival of > 95% and 10 year survival > 90%
Image source 1 - http://www.pathpedia.com/Education/eAtlas/Histopathology/Thyroid_gland/Papillary_carcinoma.aspx
Image source 2 - http://www.thefullwiki.org/Psammoma_body
Image source 3 - http://www.deltagen.com
Article by - Dr. Chirag Navadia, MedRx Education - www.medrx22.com